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Bone Marrow and Peripheral Blood Stem Cell Transplants

This document will give you an overview of bone marrow transplants and other types of stem cell transplants that are used to treat cancer. If you would like more details about donating stem cells or having a stem cell transplant, please contact the organizations listed in the "Additional resources" section.

Stem cells are cells in the bone marrow that make all of the body's blood cells. Stem cell transplants are used to restore the stem cells when the bone marrow has been destroyed by disease, chemotherapy, or radiation. Depending on the source of the stem cells, this procedure may be called a bone marrow transplant, a peripheral blood stem cell transplant, or a cord blood transplant.

The first successful bone marrow transplant was done in 1968. It was not until nearly 20 years later that stem cells taken from circulating (peripheral) blood were transplanted with success. More recently, doctors have begun using cord blood from the placenta and umbilical cords of newborn babies as another source of stem cells.

Today tens of thousands of patients have had stem cell transplants. This has lead to better care for transplant patients and helped doctors know more about which patients are likely to have better results after transplant.

What Are Stem Cells?
All of the blood cells in our bodies start out as young (immature) cells called hematopoietic (blood-forming) stem cells. Learn about the different types of stem cells and where they are found in the body.
Reasons for Stem Cell Transplants
Stem cell transplants can be an important part of cancer treatment. Learn how stem cell transplants can be used to treat cancer or to replace bone marrow that has been destroyed.
Types of Stem Cell Transplants
The type of transplant depends on where the stem cells come from. Learn the differences between the three types of stem cell transplants.
Sources of Stem Cells for Transplants
There are 3 possible sources of stem cells to use for transplants. Learn how stem cells can be extracted from bone marrow, circulating blood and umbilical cord blood.
Which Stem Cell Source Is Best?
All 3 sources of stem cells can be used for the same goal. Learn about the advantages and drawbacks to each of the sources.
Allogeneic Transplant: Importance of a Matched Donor
A working immune system recognizes cells coming from other people as foreign. Learn how doctors try to find the best match possible to avoid possible complications with allogeneic stem cell transplants.
The Donor Experience
People usually volunteer to become stem cell donors either because they have a family member in need of a match or because they want to help people they don't know. Learn what to expect from the donor experience.
The Transplant Process
There are several steps in the transplant process, no matter what type of transplant you are going to have. Learn what to expect from the transplant process.
Problems in the Post-Transplant Period
Stem cell transplants have certain risks. Learn about possible problems and what to look out for after a transplant.
What Questions Should I Ask My Doctor?
Good communication with your doctor is important. Learn some questions you may want to ask before agreeing to a transplant.
Issues Related to Stem Cell Transplants
There are a number of issues related to stem cell transplantation. Learn what issues you should take into account as you make your treatment decisions.
Additional Resources
Find additional resources for Bone Marrow & Peripheral Blood Stem Cell Transplants.
References

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